[29], Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. More Info about Chlorthalidone. Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. "Chlorthalidone." Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. chlorothiazide systemic. Atenolol/chlorthalidone is a combination of atenolol and chlorthalidone (Hygroton) used for the treatment of high blood pressure.Atenolol is a beta-adrenergic blocking agent that blocks the effects of adrenergic drugs, for example, adrenaline or epinephrine, on nerves of the sympathetic nervous system.Atenolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. Diuretics such as chlortalidone also reduce the urine concentration of concomitantly-taken performance-enhancing drugs or of their metabolites, thus making it more difficult to detect these drugs using urine testing. Nephrogenic diabetes insipidus occurs when the kidney is unable to produce concentrated urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate. chlorthalidone systemic. There is evidence that chlortalidone is superior to hydrochlorothiazide for reducing the mass of the left ventricle of the heart in persons with enlargement of the left ventricle of the heart. [42] Some of chlortalidone's diuretic effect is also due to this inhibition of carbonic anhydrase in the proximal tubule. ", "Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia", "Thiazide-Associated Hypercalcemia: Incidence and Association With Primary Hyperparathyroidism Over Two Decades", "Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies", "The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs", "Chlorthalidone: don't call it "thiazide-like" anymore", "Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response", "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis", "Yasir Shah provisionally suspended after failed drugs test", https://en.wikipedia.org/w/index.php?title=Chlortalidone&oldid=992686053, World Anti-Doping Agency prohibited substances, Drugboxes which contain changes to watched fields, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 December 2020, at 15:54. [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. [24] A secondary analysis of data from the ALLHAT study found that chlortalidone reduced risk of hip and pelvis fracture. Use in pregnancy: It is better to avoid Chlorthalidone as it crosses the placenta. [51], O=S(=O)(N)c1c(Cl)ccc(c1)C2(O)c3ccccc3C(=O)N2, InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21). THALIDON : Chlorthalidone USP 25mg/tablet: Tablet: Popular Pharmaceuticals Ltd. 30s pack: 60.00 MRP Generic chlorthalidone comes in three different strengths, ranging from 25 to 100 mg, and is manufactured by several different companies. Chlortalidone reduces reabsorption of sodium and chloride primarily through inhibition of the Na+/Cl− symporter in the apical membrane of distal convoluted tubule cells in the kidney. [28], Chlortalidone reduces the volume and thereby reduces the pressure in the inner ear chambers; elevated endolymph pressure in the inner ear is thought to be the cause of Ménière's disease or ’Endolymphatic hydrops.’ Synthesis of evidence from multiple small, low-quality studies indicates that chlortalidone or other thiazide diuretics are effective for Ménière's Disease. It helps the kidney to get rid of unwanted water and salt from the body into the urine. Chlortalidone is used to treat high blood pressure (hypertension), and is also used to lessen extra fluid in the body (called oedema) caused by conditions such as heart failure, liver disease, or kidney disease. [1] It is specifically a thiazide-like diuretic. you'll often start with a thiazide diuretic, such as: * chlorthalidone (hygroton) * chlorothiazide (diuril) * hydrochlorothiazide or hctz (esidrix, hydrodiuril, microzide) * indapamide (lozol) * Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. High blood pressure adds to the workload of the heart and arteries. Chlorthalidone - Trade Names: Amlovas-CH (5mg/12.5mg) Amlovas-CH (5mg/6.25mg) Catapres - DIU (0.1mg/15mg) Catapres DIU: Cortel- CH (40mg/12.5mg) CTD … [2] In 2017, it was the 173rd most commonly prescribed medication in the United States, with more than three million prescriptions. [1], Chlortalidone was patented in 1957 and came into medical use in 1960. Generic Name: . Chlorthalidone is a long acting thiazide-like diuretic of the sulfamoylbenzamide class that is devoid of the benzothiadiazine structure. 1-36. [16], Chlortalidone and other thiazide diuretics are effective for lowering high blood pressure in persons with chronic kidney disease, although the risk of adverse effects is higher in these persons. Drug information provided by: IBM Micromedex. [25], Chlortalidone reduces the amount of calcium excreted in urine, reducing the risk of calcium oxalate kidney stones. Documented hypersensitivity to chlorthalidone or sulfonamides. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for … Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use © All Rights Reserved 1997 - 2021. Drug Name : Chlorthalidone. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. OH I o+ s NH2 CHLORTHALIDONE 3 1.2 Trade Names Hygroto@ x Regrotoa Hydro-Long Hydroton Igroton Chlorthalidone is also a component of Regrotor@ and Demi-Regroton combination products containing Chlorthalidone in combination with reserpine. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. It is also used to prevent calcium-based kidney stones. The reduction in intravascular volume induces an elevation in plasma renin activity and aldosterone secretion, further contributing to the potassium loss associated with thiazide diuretic therapy. 14, pp. [48] Chlortalidone is freely soluble in dimethylacetamide (DMA), dimethylformamide (DMF), dimethylsulfoxide (DMSO), and methanol; it is also soluble in warm ethanol.[49]. It increases the amount of urine you make, especially when you first start the medication. CHLORTHALIDONE Pronunciation: (klor thal' i done) Trade Name(s): Hythalton, hygroton, bigroton Why it is prescribed: Chlorthalidone, a water pill, is used to treat high blood pressure and fluid retention caused by various conditions.It causes the kidney to eliminate unneeded water and salt into the urine. chlorthalidone is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. Edema may be caused by either increased hydrostatic pressure or reduced oncotic pressure in the blood vessels. [50] Sports such as wrestling or boxing categorize athletes according to body weight; taking a diuretic such as chlortalidone may lower body weight, and thereby permit an athlete to compete in a lighter weight class, which would provide an advantage. [43] Chronic exposure to chlortalidone decreases the glomerular filtration rate. High blood pressure or hypertension is a chronic condition, which usually lasts a lifetime once it is developed. Chlortalidone is banned for some sports (including cricket) because it is a diuretic, and can be used to reduce body weight or to mask the concomitant use of performance-enhancing drugs. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. Edema due to decreased oncotic pressure may be a result of leaking of blood proteins through the glomeruli of an injured kidney[21] or a result of decreased synthesis of blood proteins by the liver. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01) [3]. [7][8] While it may be used in pregnancy it is a less preferred option. [10][11], Chlortalidone is considered a first-line medication for treatment high blood pressure. They are available as follows: NDC 16714-128-01 in bottle of 100 tablets By increasing the delivery of sodium to the distal renal tubule, chlortalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i.e. [22], Chlortalidone decreases mineral bone loss by promoting calcium retention by the kidney, and by directly stimulating osteoblast differentiation and bone mineral formation. [1] It is taken by mouth. Chlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. US Brand Name. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for high blood pressure and fluid retention. 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